Methods: It was a cross-sectional study.
Meanwhile, 10 patients with atherosclerotic heart disease, who underwent coronary artery bypass grafting CABGwere selected as control group. The ascending aorta tissue specimens from patients of the two groups were collected during the operation.
Four-dimensional non-standard quantitative proteomics technology 4D-LFQ was used to detect the protein profile of ascending aorta tissue specimens of the two groups and to screen out differentially expressed proteins and analyze their biological functions. Precise quantification of the selected target proteins was achieved by parallel response monitoring PRM. Results: A total of 3 proteins were identified by 4D-LFQ technology, among which 3 proteins could be quantified.
There were 39 proteins were significantly upregulated and 47 proteins were define aneurysm medical downregulated in AAD group. The results of biological function analysis showed that most of the differentially expressed proteins were located in the extracellular, and their functions were mainly involved in cell migration and proliferation, inflammatory cell activation, cell contraction, and muscle organ development.